Population
Rats with myocardial infarction (4-6 weeks after coronary artery ligation) and congestive heart failure
Comparison
Acute pharmacological infusion of angiotensin II… vs Normal control rats
Design
Preclinical
Authors
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May underlie intrarenal vasoconstriction in experimental HF; leaves open human relevance and therapeutic targeting.
Rats with myocardial infarction exhibit a specific dysregulation and upregulation of AT1 receptors in renal glomeruli, which may contribute to intrarenal vasoconstriction in heart failure.
Mento et al. (1998) studied this question.
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