Why the study?
Does ACE inhibition or AT1 receptor blockade prevent cardiac remodeling and alter tissue angiotensin II dynamics in a pig model of myocardial infarction?
Population
49 pigs undergoing coronary artery ligation (myocardial infarction model) or sham operation
Comparison
Captopril or eprosartan vs Sham operation or untreated myocardial infarction
Design
Preclinical
Follow-up
up to 6 weeks
Authors
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Suggests AT2 stimulation attenuates remodeling in pig MI; hypothesis-generating and should not change practice.
Does ACE inhibition or AT1 receptor blockade prevent cardiac remodeling and alter tissue angiotensin II dynamics in a pig model of myocardial infarction?
In a pig model of MI, ACE inhibition and AT1 receptor blockade attenuate cardiac remodeling, potentially through increased stimulation of growth-inhibitory AT2 receptors by locally generated Ang II.
Kats et al. (2000) studied this question.
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