Angiotensin II receptor blockade and ventricular remodelling
Why the study?
Do Angiotensin II receptor blockers, alone or combined with ACE inhibitors, attenuate ventricular remodelling in patients with acute myocardial infarction or congestive heart failure?
Population
Patients with acute myocardial infarction and/or congestive heart failure
Comparison
Angiotensin II receptor blockers alone or in… vs ACE inhibitors alone or either agent alone
Design
Review
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for dual ACEI/ARB blockade post-injury; prospective RCTs needed before clinical adoption.
Structured PICO
Do Angiotensin II receptor blockers, alone or combined with ACE inhibitors, attenuate ventricular remodelling in patients with acute myocardial infarction or congestive heart failure?
P
Population
Patients with acute myocardial infarction and/or congestive heart failure
I
Intervention
Angiotensin II receptor blockers (ARBs) alone or in combination with ACE inhibitors
C
Comparator
ACE inhibitors alone or either agent alone
O
Outcome
Ventricular remodelling (LV volumes, LV dilatation, hypertrophy, and systolic function)surrogate
Simultaneous use of ACE inhibitors and ARBs may provide greater benefit in attenuating ventricular remodelling than either agent alone following cardiac injury.
Cite This Study
Anavekar et al. (2005) studied this question.