Why the study?
Does ACE inhibitor administration prevent left ventricular remodeling after myocardial infarction in AT1 receptor knockout mice?
Does ACE inhibitor administration prevent left ventricular remodeling after myocardial infarction in AT1 receptor knockout mice?
ACE inhibitors prevent post-MI left ventricular remodeling through mechanisms independent of the AT1 receptor, as demonstrated by their efficacy in AT1 knockout mice.
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ACE inhibitor effects in AT1-knockout mice warrant mechanistic follow-up; leaves open human relevance and does not alter practice.
Mitsuharu Yoshiyama (2005) studied this question.
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