Why the study?
Does losartan improve extracellular matrix remodeling and alter Ang II binding kinetics in a rat model of myocardial infarction?
Does losartan improve extracellular matrix remodeling and alter Ang II binding kinetics in a rat model of myocardial infarction?
Losartan treatment in a rat model of myocardial infarction attenuates adverse extracellular matrix remodeling and increases Ang II binding affinity for the AT2 receptor, suggesting potential cardioprotective mechanisms.
Authors
No takes yet. Share an insight, caveat, or question.
Losartan effects in rat MI model should not change practice; leaves open AT2 affinity hypotheses for remodeling in future translational studies.
El‐Sabban et al. (2000) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: