Key result
Losartan treatment in post-MI rats significantly decreased cardiac fibrosis and immunoreactive prolyl 4-hydroxylase, attenuating cardiac hypertrophy and improving left ventricular function.
Why the study?
Does losartan reduce cardiac fibrosis and improve LV function in post-MI rats?
Population
Post-myocardial infarction (MI) rat model and sham-operated control rats
Comparison
Losartan (15 mg/kg/day) vs Untreated post-MI rats and sham-operated rats
Design
Preclinical
Follow-up
1, 2, or 4 weeks
Authors
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Supports AT1 blockade for post-MI remodeling in rats; leaves open clinical translation pending human studies.
Does losartan reduce cardiac fibrosis and improve LV function in post-MI rats?
AT1 receptor blockade with losartan attenuates cardiac fibrosis and hypertrophy while improving LV function in post-MI rats, potentially via suppression of prolyl 4-hydroxylase.
H Ju (1997) studied myocardial infarction. losartan vs. untreated post-MI rats and sham-operated controls was evaluated on cardiac collagen remodeling (collagen mRNA abundance, posttranslational hydroxylation, mature collagen deposition). Losartan treatment in post-MI rats significantly decreased cardiac fibrosis and immunoreactive prolyl 4-hydroxylase, attenuating cardiac hypertrophy and improving left ventricular function.
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