April 1, 1996Cardiovascular Research

The effect of AT1 receptor antagonist on chronic cardiac response to coronary artery ligation in rats

View Full Paper

Ask AI

Bookmark

Why the study?

Does losartan improve hemodynamics and morphometric changes in adult male rats with experimental myocardial infarction?

Population

Adult male rats with experimental myocardial infarction induced by coronary artery ligation

Comparison

Losartan (AT1 receptor antagonist) vs Untreated controls with experimental infarction…

Design

Preclinical

Authors

TST SládekUniversity of Ottawa JSJana SládkováCharles University FPF PapoušekCzech Academy of Sciences

Discussion

Member takes

Implication

Losartan may improve post-MI hemodynamics and angiogenesis in rats; leaves open translation to human therapy.

Structured PICO

Does losartan improve hemodynamics and morphometric changes in adult male rats with experimental myocardial infarction?

Population

Adult male rats with experimental myocardial infarction induced by coronary artery ligation

Intervention

Losartan (AT1 receptor antagonist)

Comparator

Untreated controls with experimental infarction and sham-operated animals

Outcome

Hemodynamic and morphometric changes (including left ventricular end-diastolic pressure, relaxation constant tau, right ventricular systolic pressure, and capillary density)surrogate

Losartan improves hemodynamics and promotes coronary angiogenesis following experimental myocardial infarction in rats.

Cite This Study

Sládek et al. (1996) studied this question.

synapsesocial.com/papers/6a7e2aed760ccf6bd099095f https://doi.org/10.1016/s0008-6363(95)00244-8

View Full Paper

Ask AI

Bookmark

The effect of AT1 receptor antagonist on chronic cardiac response to coronary artery ligation in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The effect of AT1 receptor antagonist on chronic cardiac response to coronary artery ligation in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider