December 1, 2000Arquivos Brasileiros de CardiologiaOpen Access

Effects of losartan on ventricular remodeling in experimental infarction in rats

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Why the study?

Does losartan improve survival and attenuate ventricular remodeling in a rat model of myocardial infarction?

Population

84 surviving male Wistar rats after surgical occlusion of left coronary artery

Comparison

Losartan 20mg/kg/day vs No medication

Design

Preclinical

Follow-up

3 months

Authors

LZLeonardo Antônio Mamede ZornoffUniversidade Estadual Paulista (Unesp)LMLuiz Shiguero MatsubaraUniversidade Estadual Paulista (Unesp)BMBeatriz B. MatsubaraUniversidade Estadual Paulista (Unesp)

Discussion

Member takes

Implication

Hypothesis-generating for losartan post-MI remodeling; prospective human trials needed before clinical adoption.

Structured PICO

Does losartan improve survival and attenuate ventricular remodeling in a rat model of myocardial infarction?

Population

84 surviving male Wistar rats after surgical occlusion of left coronary artery

Intervention

Losartan 20mg/kg/day

Comparator

No medication

Outcome

Mortality and ventricular remodeling parameters (ventricular to body mass ratio, myocardial hydroxyproline concentration, isovolumetric pressure, +dp/dt, -dp/dt, and diastolic volume/left ventricle mass ratio) at 3 monthssurrogate

In a rat model of myocardial infarction, losartan improved survival and attenuated ventricular remodeling and hypertrophy.

Cite This Study

Zornoff et al. (2000) studied this question.

synapsesocial.com/papers/6a70abf0660549caf2c54ba2 https://doi.org/10.1590/s0066-782x2000001200001

View Full Paper

Ask AI

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Effects of losartan on ventricular remodeling in experimental infarction in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of losartan on ventricular remodeling in experimental infarction in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider