Why the study?
Does early versus late losartan administration improve post-MI ventricular remodeling in rabbits?
Population
Rabbits with myocardial infarction
Comparison
Losartan (12.5 mg.kg.day) initiated early or… vs Untreated MI rabbits and sham-operated rabbits
Design
Preclinical
Follow-up
Up to 56 days
Authors
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Caution against long-term losartan post-MI; leaves open optimal duration and human translation of AT1 blockade.
Does early versus late losartan administration improve post-MI ventricular remodeling in rabbits?
In a rabbit model of MI, long-term AT1 receptor blockade with losartan unfavorably modifies ventricular remodeling and delays wound healing, highlighting species-specific differences in the renin-angiotensin system response.
Gónzalez et al. (2009) studied this question.
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