Effects of pre-, peri-, and postmyocardial infarction treatment with losartan in rats: effect of dose on survival, ventricular arrhythmias, function, and remodeling

Male Wistar rats (n = 502) subjected to myocardial infarction

Losartan started 7 days pre-MI and continued peri- and post-MI, administered as either a high dose (30 mg/kg/day) or a progressively increasing dose (3 mg/kg/day increased to 10 mg/kg/day at 10 days and 30 mg/kg/day at 20 days post-MI)

No treatment (control)

Survival at 24 hours post-MI and from 24 hours to 38 days post-MIhard clinical