Key result
Losartan treatment partially reversed cardiac remodelling, improved cardiac performance, and partially recovered sarcoplasmic reticular and myofibrillar functions in rats with MI-induced heart failure.
Why the study?
Does losartan reverse subcellular remodelling and improve cardiac function in rats with heart failure due to myocardial infarction?
Population
Rats with heart failure due to myocardial infarction (MI induced 12 weeks prior to treatment)
Comparison
Losartan 20 mg/kg daily for 8 weeks vs No losartan treatment
Design
Preclinical
Follow-up
8 weeks
Authors
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Should not change post-MI HF management; leaves open translation of losartan remodeling effects beyond rat models.
Does losartan reverse subcellular remodelling and improve cardiac function in rats with heart failure due to myocardial infarction?
In a rat model of post-MI heart failure, losartan partially reverses cardiac remodeling and improves subcellular sarcoplasmic reticular and myofibrillar functions.
Babick et al. (2012) studied Heart failure due to myocardial infarction. Losartan vs. Without losartan was evaluated on Cardiac function, cardiac remodelling, subcellular alterations and plasma catecholamines. Losartan treatment partially reversed cardiac remodelling, improved cardiac performance, and partially recovered sarcoplasmic reticular and myofibrillar functions in rats with MI-induced heart failure.
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