Why the study?
Does losartan prevent contractile dysfunction in rat myocardium after left ventricular myocardial infarction?
Population
Rat model of left ventricular myocardial infarction induced by ligation of the left anterior descending…
Comparison
Losartan 30 mg/kg/day orally vs Untreated myocardial infarction rats and…
Design
Preclinical
Follow-up
12 weeks
Authors
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Losartan may preserve post-MI contractility in rats; hypothesis-generating and should not yet alter clinical practice.
Does losartan prevent contractile dysfunction in rat myocardium after left ventricular myocardial infarction?
In a rat model of myocardial infarction, chronic losartan treatment prevents right ventricular contractile dysfunction, likely by improving myocyte calcium homeostasis rather than myofilament function.
Daniels et al. (2001) studied this question.
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