Why the study?
Does captopril or losartan improve cardiac pump performance in rats after myocardial infarction?
Does captopril or losartan improve cardiac pump performance in rats after myocardial infarction?
In a rat model of myocardial infarction, both captopril and losartan improved cardiac pump performance, though captopril had more pronounced effects on reducing end-diastolic pressure and decreasing peak rates of pressure change.
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Animal data on partial pump improvement remain preliminary; leaves open comparative ACEI versus ARB effects in human post-MI remodeling.
Capasso et al. (1994) studied this question.
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