Why the study?
Does captopril improve cardiac hypertrophy and hemodynamics in a rat model of myocardial infarction?
Population
Experimental myocardial infarction (MI) rats
Comparison
Captopril administered for 1 to 4 weeks vs Non-treated MI rats and controls
Design
Preclinical
Follow-up
up to 4 weeks
Authors
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Hypothesis-generating for ACEI effects on post-MI remodeling in rats; leaves open translation to human therapy.
Does captopril improve cardiac hypertrophy and hemodynamics in a rat model of myocardial infarction?
Captopril induces regression of cardiac hypertrophy and improves hemodynamics in a rat model of myocardial infarction, suggesting benefits from both preload and afterload reduction.
Shigeto Naito (1992) studied this question.
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