Key result
Captopril treatment for 5 weeks in rats with postinfarction heart failure partially normalized myocardial contractility and intracellular calcium handling compared to untreated infarcted rats.
Why the study?
Does captopril improve contractile function and calcium handling in myocardium from rats with postinfarction heart failure?
Population
Rats with postinfarction heart failure, sham-operated rats, and captopril-treated infarcted rats
Comparison
Captopril for 5 weeks, beginning 1 week after… vs Untreated infarcted rats and sham-operated rats
Design
Preclinical
Follow-up
5 weeks
Authors
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Does not support clinical translation from rat models; extends preclinical data on load reduction in experimental heart failure.
Does captopril improve contractile function and calcium handling in myocardium from rats with postinfarction heart failure?
Chronic load reduction with captopril partially normalizes the defect in excitation-contraction coupling and beta-adrenergic responsiveness in postinfarction heart failure.
Litwin et al. (1992) studied Postinfarction heart failure (n=48). Captopril vs. Untreated infarcted rats and sham-operated rats was evaluated on Contractile function and intracellular calcium handling. Captopril treatment for 5 weeks in rats with postinfarction heart failure partially normalized myocardial contractility and intracellular calcium handling compared to untreated infarcted rats.