What question did this study set out to answer?

This research aims to evaluate the effects of captopril on ischemic burden and left ventricular dysfunction post-myocardial infarction.

April 1, 1993CirculationOpen Access

Effects of captopril on ischemia and dysfunction of the left ventricle after myocardial infarction.

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Why the study?

Does captopril reduce ischemia and improve left ventricular dysfunction in patients with left ventricular dysfunction after myocardial infarction?

Population

64 patients with left ventricular dysfunction after myocardial infarction

Comparison

Captopril 50 mg daily started at day 7… vs Placebo

Design

RCT, Randomized at day 7, Double-blind

Follow-up

6 months

Authors

PSPeter SøgaardHeart Failure & Transplant CGCarl-Otto GøtzscheAalborg University Hospital JRJan RavkildeInterventional Cardiology

Discussion

Member takes

Implication

Supports captopril to reduce post-MI ischemia and prevent LV dilation in dysfunction; extends ACEI benefits to functional and remodeling endpoints.

Key Points

This research aims to evaluate the effects of captopril on ischemic burden and left ventricular dysfunction post-myocardial infarction.
Randomized, double-blind, placebo-controlled trial
64 patients with left ventricular dysfunction received either captopril (50 mg daily) or placebo for 6 months
Follow-up assessed using ambulatory ECG, bicycle ergometer, and echocardiography.
Captopril group showed significantly reduced ST segment depression (87 min vs. 638 min in placebo, p < 0.001)
Working capacity increased significantly in the captopril group (from 540 to 738 seconds, p < 0.01, compared to placebo)
Dilation of left ventricle volumes was prevented in captopril group, while end-systolic volume decreased (p < 0.05).

Structured PICO

Does captopril reduce ischemia and improve left ventricular dysfunction in patients with left ventricular dysfunction after myocardial infarction?

Population

64 patients with left ventricular dysfunction after myocardial infarction

Intervention

Captopril 50 mg daily started at day 7 post-myocardial infarction for 6 months

Comparator

Placebo

Outcome

Duration of ST segment depression on ambulatory ECG, working capacity on bicycle ergometer, and left ventricular volumes on echocardiography at 6 monthssurrogate

Captopril reduces ischemic burden, increases working capacity, and prevents left ventricular dilation in patients with left ventricular dysfunction following myocardial infarction.

Cite This Study

Søgaard et al. (1993) studied this question.

synapsesocial.com/papers/6a03bfe1d2c35e4200e96b00 https://doi.org/10.1161/01.cir.87.4.1093

Topics

Echocardiography Women and heart disease

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Implication

Supports captopril to reduce post-MI ischemia and prevent LV dilation in dysfunction; extends ACEI benefits to functional and remodeling endpoints.

Effects of captopril on ischemia and dysfunction of the left ventricle after myocardial infarction.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Effects of captopril on ischemia and dysfunction of the left ventricle after myocardial infarction.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider