Why the study?
Does captopril improve hemodynamics and clinical status in patients with severe chronic heart failure on digitalis and diuretics?
Population
23 patients with severe chronic heart failure on treatment with digitalis and diuretics.
Comparison
Captopril added to background therapy over a… vs Placebo added to background therapy over a…
Design
RCT, randomized, double-blind
Follow-up
6 months
Authors
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Supports captopril addition in severe HF on digitalis/diuretics; confirms ACEI hemodynamic benefits in this RCT population.
Does captopril improve hemodynamics and clinical status in patients with severe chronic heart failure on digitalis and diuretics?
Long-term treatment with captopril in severe heart failure leads to persistent hemodynamic improvement, increased renal blood flow, and clinical symptom relief by unloading the myocardium.
Bussmann et al. (1987) studied this question.
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