July 14, 1988New England Journal of Medicine
Effect of Captopril on Progressive Ventricular Dilatation after Anterior Myocardial Infarction
Why the study?
Does captopril attenuate progressive ventricular dilatation and improve hemodynamics and exercise capacity in patients with a recent anterior myocardial infarction and LVEF ≤45%?
Population
59 patients with a first anterior myocardial infarction and a radionuclide ejection fraction of 45 percent…
Comparison
Captopril vs Placebo
Design
RCT, randomly assigned, double-blind, placebo-controlled
Follow-up
one year
Authors
Discussion
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Member takes
Implication
Supports captopril post-anterior MI with LVEF ≤45%; extends ACE-inhibitor evidence to limit ventricular remodeling.
Structured PICO
Does captopril attenuate progressive ventricular dilatation and improve hemodynamics and exercise capacity in patients with a recent anterior myocardial infarction and LVEF ≤45%?
P
Population
59 patients with a first anterior myocardial infarction and a radionuclide ejection fraction of 45 percent or less, 11 to 31 days post-infarction, not in overt congestive heart failure.
I
Intervention
Captopril
C
Comparator
Placebo
O
Outcome
Interval changes in hemodynamic function and left ventricular volume (end-diastolic volume) at one yearsurrogate
Captopril attenuates progressive ventricular enlargement, reduces filling pressures, and improves exercise tolerance in patients recovering from an anterior myocardial infarction with reduced ejection fraction.
Limitations
- Preliminary study
Cite This Study
Pfeffer et al. (1988) studied this question.