Why the study?
Does captopril or frusemide improve left ventricular volumes and function and prevent clinical heart failure in patients with asymptomatic left ventricular dysfunction following myocardial infarction?
Population
90 patients with asymptomatic left ventricular dysfunction 1 week following Q wave myocardial infarction
Comparison
Captopril 25 mg three times daily or frusemide… vs Placebo
Design
RCT, randomized, double-blind
Follow-up
12 months
Authors
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Captopril warrants use in asymptomatic post-MI LV dysfunction to preserve EF and avert HF; confirms remodeling benefits in this RCT.
Does captopril or frusemide improve left ventricular volumes and function and prevent clinical heart failure in patients with asymptomatic left ventricular dysfunction following myocardial infarction?
Captopril improves asymptomatic ventricular dysfunction and prevents progressive ventricular dilatation and clinical heart failure during the year following a Q-wave myocardial infarction.
Sharpe et al. (1990) studied this question.
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