Key result
Captopril treatment in rats with large myocardial infarctions attenuated the prolongation in time to peak tension but did not normalize developed tension or muscle stiffness.
Why the study?
Does captopril improve contractility and stiffness of noninfarcted myocardium after myocardial infarction in rats?
Population
Rats 6 weeks after sham operation or myocardial infarction (coronary ligation model)
Comparison
Captopril treatment beginning 3 weeks after… vs Untreated rats with myocardial infarction and…
Design
Preclinical
Follow-up
6 weeks post-infarction (3 weeks of treatment)
Authors
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Should not yet inform clinical ACEI use post-MI; leaves open whether remodeling benefits extend to normalized contractility and stiffness.
Does captopril improve contractility and stiffness of noninfarcted myocardium after myocardial infarction in rats?
In a rat model of myocardial infarction, captopril alters cardiac remodeling and improves some parameters of contractility in noninfarcted myocardium, but intrinsic contractile dysfunction and stiffness persist.
Litwin et al. (1991) studied Myocardial infarction. Captopril vs. Untreated myocardial infarction rats was evaluated on Isometric function and passive myocardial stiffness. Captopril treatment in rats with large myocardial infarctions attenuated the prolongation in time to peak tension but did not normalize developed tension or muscle stiffness.
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