Why the study?
Does angiotensin II administration alter the contractile response of myocardium in rats with infarction-induced heart failure compared to controls?
Population
Sprague-Dawley rats at 2 months of age with surgically induced large infarcts (coronary arterial occlusion)
Comparison
Angiotensin II administration to isolated left… vs Papillary muscles from control rats, evaluated…
Design
Preclinical
Follow-up
48 hours post-infarction
Authors
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Warrants caution extrapolating ANG II effects from healthy to failing myocardium; leaves open human HF relevance.
Does angiotensin II administration alter the contractile response of myocardium in rats with infarction-induced heart failure compared to controls?
Infarction-induced heart failure in rats potentiates the negative inotropic effect of angiotensin II on myocardial contractile performance.
Capasso et al. (1993) studied this question.
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