Key result
ANG II infusion in rats with and without MI had comparable negative effects on cardiac function, but caused only a minor increase in blood pressure in MI rats compared to a 70 mm Hg increase in sham rats.
Why the study?
Does Angiotensin II infusion alter cardiac function and peripheral vascular structure differently in rats with compensated heart failure compared to sham-operated rats?
Population
Myocardial-infarcted (MI) and sham-operated rats
Comparison
Angiotensin II infusion for 2 weeks vs Saline (0.9% NaCl) infusion
Design
Preclinical
Follow-up
2 weeks
Authors
Loading...
Ang II pressor effects appear attenuated in compensated HF models; hypothesis-generating for counter-regulation, should not change practice.
Does Angiotensin II infusion alter cardiac function and peripheral vascular structure differently in rats with compensated heart failure compared to sham-operated rats?
In a rat model of compensated heart failure, the hypertensive and vascular growth-stimulatory effects of Angiotensin II are blunted, potentially due to counter-regulation by increased ANP and NO synthase activity.
Heeneman et al. (1997) studied Compensated heart failure. Angiotensin II (ANG II) vs. Saline (0.9% NaCl) was evaluated on Cardiac function and peripheral vascular changes. ANG II infusion in rats with and without MI had comparable negative effects on cardiac function, but caused only a minor increase in blood pressure in MI rats compared to a 70 mm Hg increase in sham rats.