Why the study?
Does angiotensin II infusion increase myocardial contractility in intact and sinoaortic denervated isoflurane-anesthetized rabbits?
Population
Intact and chronically sinoaortic denervated isoflurane-anesthetized rabbits
Comparison
Angiotensin II infusion (50 ng/kg per min) vs Basal conditions (prior to infusion)
Design
Preclinical
Follow-up
Short-term (during infusion)
Authors
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No direct inotropic effect in this anesthetized rabbit model; leaves open translation to conscious animals or human physiology.
Does angiotensin II infusion increase myocardial contractility in intact and sinoaortic denervated isoflurane-anesthetized rabbits?
Angiotensin II infusion in anesthetized rabbits increases ventricular pre- and after-loads but exerts no significant direct effect on cardiac contractility.
Marano et al. (1997) studied this question.
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