Population
Isolated perfused rabbit hearts and collagenase-dissociated paced adult rabbit ventricular myocytes loaded…
Comparison
Angiotensin II infusion vs Change in perfusate [Ca2+] from 0.9 to 3.6 mM
Design
Preclinical
Authors
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Should not yet change clinical management; leaves open whether pH modulation extends Ang II inotropy concepts to human HF models.
Angiotensin II increases myocardial contractility via increased myofilament Ca2+ sensitivity due to intracellular alkalosis, rather than increased free cytosolic Ca2+.
Ikenouchi et al. (1994) studied this question.
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