Key result
Angiotensin II produced a positive inotropic effect in cat ventricular myocytes by increasing the intracellular Ca2+ transient, primarily through enhancement of the L-type Ca2+ current, independent of pH changes.
Population
Isolated cat ventricular myocytes
Comparison
Angiotensin II (1 microM) vs Control (baseline/absence of Angiotensin II)
Design
Preclinical
Authors
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Angiotensin II calcium effects remain preclinical; leaves open translation to human inotropy or heart failure therapy.
Effect estimate: 163 ± 22 % increase
In cat ventricular myocytes, the positive inotropic effect of Angiotensin II is driven by an increase in the intracellular Ca2+ transient via enhanced L-type Ca2+ current, independent of intracellular pH changes or myofilament Ca2+ responsiveness.
Petroff et al. (2000) studied Normal myocardium (cat ventricular myocytes). Angiotensin II vs. Control (baseline) was evaluated on Maximal increase in contraction amplitude (163 ± 22 % increase). Angiotensin II produced a positive inotropic effect in cat ventricular myocytes by increasing the intracellular Ca2+ transient, primarily through enhancement of the L-type Ca2+ current, independent of pH changes.
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