What question did this study set out to answer?

To investigate the inotropic effects of synthetic angiotensin on isolated papillary muscles and myocardium.

April 1, 1964Circulation ResearchOpen Access

Myocardial Actions of Angiotensin

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Population

Isolated papillary muscles of kittens, cat atrial muscle, and frog ventricular myocardium

Comparison

Synthetic angiotensin vs Equimolar concentrations of l-norepinephrine and…

Design

Preclinical

Authors

JKJan Koch‐WeserElectrophysiology

Discussion

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Implication

Hypothesis-generating for direct myocardial inotropy by angiotensin in mammals; human studies needed before clinical consideration.

Key Points

To investigate the inotropic effects of synthetic angiotensin on isolated papillary muscles and myocardium.
Isolated papillary muscles were contracted isometrically to measure tension development.
Experimental concentrations of synthetic angiotensin ranged from 10^-10 M to 10^-5 M.
Comparative assessment with l-norepinephrine at equimolar concentrations.
Mean maximum increase in tension development with angiotensin was 120%.
Low concentrations of angiotensin demonstrate greater inotropic action than l-norepinephrine, but maximum effect of l-norepinephrine is almost double that of angiotensin.
No impact on resting length-tension relationship or impulse frequency in the SA node.

Structured PICO

Population

Isolated papillary muscles of kittens, cat atrial muscle, and frog ventricular myocardium

Intervention

Synthetic angiotensin (concentrations from 10^-10 M to 10^-5 M)

Comparator

Equimolar concentrations of l-norepinephrine and levarterenol

Outcome

Inotropic effects (tension development and contractility)surrogate

Synthetic angiotensin demonstrates a strong positive inotropic effect on mammalian ventricular myocardium without causing ectopic impulses, which may contribute to its pressor action in intact circulation.

Cite This Study

Jan Koch‐Weser (1964) studied this question.

synapsesocial.com/papers/6a1008ead13714ec96ff08cf https://doi.org/10.1161/01.res.14.4.337

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Myocardial Actions of Angiotensin

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Myocardial Actions of Angiotensin

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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