What does this research mean for the field?

The administration of angiotensin results in a depression of myocardial contractility in intact organisms, regardless of whether the myocardium is normal or diseased. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1975The Journal of Clinical Pharmacology

The Effect of Angiotensin on Myocardial Contractility

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Why the study?

Does angiotensin infusion reduce myocardial contractility in normal and diseased human and canine hearts?

Population

25 subjects total: 5 normal human subjects, 6 patients with cardiomyopathy, 8 normal mongrel dogs, and 6…

Comparison

Angiotensin infusion at dosages titrated to… vs Baseline measurements before angiotensin infusion.

Design

Other

Authors

SAShafiuddin AhmedRutgers, The State University of New Jersey GLGilbert E. LevinsonRutgers, The State University of New Jersey AWAllen B. WeisseRutgers, The State University of New Jersey

Discussion

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Implication

Angiotensin may depress contractility in normal and diseased hearts; leaves open effects on clinical outcomes and long-term management.

Structured PICO

Does angiotensin infusion reduce myocardial contractility in normal and diseased human and canine hearts?

Population

25 subjects total: 5 normal human subjects, 6 patients with cardiomyopathy, 8 normal mongrel dogs, and 6 dogs with ischemic myocardial scarring.

Intervention

Angiotensin infusion at dosages titrated to produce 15-20 mm Hg increases in aortic diastolic pressure.

Comparator

Baseline measurements before angiotensin infusion.

Outcome

Left ventricular myocardial contractility, measured by contractile element velocity at peak dP/dt (Vce) and the Frank-Levinson contractility index (CyIx).surrogate

Angiotensin infusion acutely depresses left ventricular myocardial contractility in both normal and diseased hearts across human and canine models.

Cite This Study

Ahmed et al. (1975) studied this question.

synapsesocial.com/papers/6a1be077b33628da419cf57d https://doi.org/10.1002/j.1552-4604.1975.tb01449.x

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The Effect of Angiotensin on Myocardial Contractility

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Effect of Angiotensin on Myocardial Contractility

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider