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July 1, 1993AJP Heart and Circulatory Physiology

Angiotensin II increases cardiac protein synthesis in adult rat heart

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Why the study?

Does angiotensin II infusion attenuate cardiac muscle atrophy and increase protein synthesis in adult rats with transplanted hearts?

Population

Adult rats with transplanted (denervated) hearts

Comparison

Angiotensin II dissolved in saline infused at a… vs Normal saline infused at 1 microliter/h for 1 week

Design

Preclinical

Follow-up

1 week

Authors

DGDavid L. GeenenGrand Valley State UniversityAMAshwani MalhotraAlbert Einstein College of MedicineJSJ. ScheuerAlbert Einstein College of Medicine

Discussion

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Implication

Angiotensin II may modulate denervated cardiac mass; leaves open translation to human transplant or atrophy settings.

Structured PICO

Does angiotensin II infusion attenuate cardiac muscle atrophy and increase protein synthesis in adult rats with transplanted hearts?

P
Population
Adult rats with transplanted (denervated) hearts
I
Intervention
Angiotensin II (ANG II) dissolved in saline infused at a subpressor dose of 3 micrograms.kg-1.h-1 for 1 week
C
Comparator
Normal saline infused at 1 microliter/h for 1 week
O
Outcome
Left ventricular (LV) mass and total LV protein synthesissurrogate

In a denervated rat heart model, subpressor doses of angiotensin II directly increase cardiac protein synthesis and attenuate cardiac atrophy without affecting hemodynamics.

Cite This Study

Geenen et al. (1993) studied this question.

synapsesocial.com/papers/6a728cbb26a7f98052de5a52https://doi.org/10.1152/ajpheart.1993.265.1.h238

Topics

Heart transplantation
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II–Induced Growth Responses in Isolated Adult Rat Hearts1995 · 201 citations
  2. 2Angiotensin II Induces Cardiac Phenotypic Modulation and Remodeling In Vivo in Rats1995 · 250 citations
  3. 3Effects of Angiotensin II on Cardiac Function and Peripheral Vascular Structure During Compensated Heart Failure in the Rat1997 · 14 citations
  4. 4Angiotensin II stimulation of protein synthesis and cell growth in chick heart cells1990 · 355 citations
  5. 5Transmural distribution of biochemical markers of total protein and collagen synthesis, myocardial contraction speed and capillary density in the rat left ventricle in angiotensin ll‐induced hypertension1988 · 10 citations