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October 1, 1992Journal of Hypertension

Subpressor angiotensin II is a bifunctional growth factor of vascular muscle in rats

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Why the study?

Does subpressor angiotensin II stimulate vascular growth in vivo in young adult male Sprague-Dawley rats?

Population

Young adult, male Sprague-Dawley rats

Comparison

Angiotensin II, 200 ng/kg per min… vs Sham-infused rats

Design

Preclinical

Follow-up

24 hours or 7-10 days

Authors

GSGéza SimonUniversity of MinnesotaSASteven AltmanUniversity of Minnesota Medical Center

Discussion

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Implication

No immediate clinical implications; leaves open whether angiotensin II trophic effects contribute to slow pressor action in human hypertension.

Key Points

  • To test whether subpressor doses of angiotensin II stimulate vascular smooth muscle growth in vivo independently of changes in arterial blood pressure.
  • Young adult male Sprague-Dawley rats received continuous intraperitoneal infusions of angiotensin II (200 ng/kg per min via osmotic minipump) or sham control for 24 hours or 7–10 days.
  • Ex vivo synthesis of protein (35S-methionine), proteoglycans (35S-sulfate), and DNA (3H-thymidine) was quantified in aortic media, portal vein, bladder wall, and diaphragm alongside systolic blood pressure monitoring.
  • At 24 hours, systolic blood pressure remained unchanged while protein synthesis and proteoglycan synthesis increased in aortic media, portal vein, and bladder wall, whereas DNA synthesis in aortic media was reduced.
  • At 7–10 days, systolic blood pressure increased, aortic protein synthesis returned to baseline, and DNA synthesis exhibited a bimodal response: remaining inhibited in 53% of rats (n = 10) and increasing two- to threefold in 26% (n = 5).

Structured PICO

Does subpressor angiotensin II stimulate vascular growth in vivo in young adult male Sprague-Dawley rats?

P
Population
Young adult, male Sprague-Dawley rats
I
Intervention
Angiotensin II, 200 ng/kg per min intraperitoneally by osmotic minipump, for 24 h or 7-10 days
C
Comparator
Sham-infused rats
O
Outcome
Protein (35S-methionine) synthesis, proteoglycan (35S-sulfate) synthesis, and DNA (3H-thymidine) synthesis measured ex vivosurrogate

Angiotensin II has a bifunctional trophic action on vascular muscle in vivo, suggesting vascular hypertrophy may contribute to its slow pressor action.

Cite This Study

Simon et al. (1992) studied this question.

synapsesocial.com/papers/6a885ac6af2c2bd0114dee69https://doi.org/10.1097/00004872-199210000-00009
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stimulation of vascular glycosaminoglycan synthesis by subpressor angiotensin II in rats.1994 · 18 citations
  2. 2Angiotensin II causes vascular hypertrophy in part by a non-pressor mechanism.1991 · 396 citations
  3. 3Development of structural vascular changes with subpressor angiotensin II administration in rats1995 · 28 citations
  4. 4Angiotensin II induces cardiovascular hypertrophy in perindopril-treated rats1995 · 38 citations
  5. 5Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo2004 · 19 citations