Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 10, 2004BMC Cardiovascular DisordersOpen Access

Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo

View Full Paper
Ask AI
Bookmark
Share

Population

Male Sprague-Dawley rats weighing 300-325 g

Comparison

Angiotensin II infusion for 24 hours, with… vs Conscious control animals receiving vehicle

Design

Preclinical

Follow-up

24 hours

Authors

CDChristine DaigleUniversité de MontréalFMFabrice M A C MartensAmsterdam NeuroscienceDGDaphné GirardotCentre National de la Recherche Scientifique

Discussion

Loading...

Member takes

Implication

Does not alter hypertension management; extends preclinical evidence for vessel-specific ERK1/2 and mTOR pathways in vascular remodeling.

Structured PICO

P
Population
Male Sprague-Dawley rats weighing 300-325 g
I
Intervention
Angiotensin II infusion (400 ng/kg/min) for 24 hours, with pharmacological agents (PD98059, rapamycin, or irbesartan) injected 5 hours before the end of infusion
C
Comparator
Conscious control animals receiving vehicle
O
Outcome
Rate of protein synthesis in the aorta and small mesenteric arteries (measured by tritiated leucine incorporation over 4 hours)surrogate

In vivo, angiotensin II induces pressure-independent vascular protein synthesis mediated by ERK1/2 in conduit arteries and rapamycin-sensitive pathways in both conduit and resistance arteries.

Limitations

  • Low number of animals
  • Pharmacokinetic profile of drugs affecting signaling cascades is seldom known
  • Complex cellular microenvironment in vivo prevents resolving direct relationship between agonist and effector pathways

Cite This Study

Daigle et al. (2004) studied this question.

synapsesocial.com/papers/6a909458e16d749e8fc92bcchttps://doi.org/10.1186/1471-2261-4-6
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Angiotensin II Infusion and Inhibition of Nitric Oxide Synthase on the Rat Aorta1996 · 45 citations
  2. 2Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells.1988 · 1,073 citations
  3. 3Effect of Angiotensin II Type 1 Receptor Blockade on Cardiac Remodeling in Angiotensin II Type 2 Receptor Null Mice2002 · 92 citations
  4. 4Chronic hyperinsulinaemia and hypertension1995 · 38 citations
  5. 5Angiotensin II stimulates DNA and protein synthesis in vascular smooth muscle cells from human arteries1999 · 119 citations