Key result
A 3-day treatment with Angiotensin II increased protein synthesis and decreased proliferation in cultured rat adrenal glomerulosa cells via p42/p44mapk and p38 MAPK pathways.
Why the study?
Does Angiotensin II stimulate cell proliferation and/or hypertrophy in primary cultures of rat adrenal glomerulosa cells?
Population
Primary cultures of rat adrenal glomerulosa cells
Comparison
Angiotensin II for 3 days, with or without… vs Control cells (untreated)
Design
Preclinical
Follow-up
3 days
Authors
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Ang II may favor hypertrophy over proliferation in rat glomerulosa cells; hypothesis-generating for adrenal remodeling in vivo.
Does Angiotensin II stimulate cell proliferation and/or hypertrophy in primary cultures of rat adrenal glomerulosa cells?
Angiotensin II acts primarily as a stimulus for steroid synthesis rather than a proliferating factor in rat adrenal glomerulosa cells, mediated by MAPK pathways.
Otis et al. (2004) studied Primary cultures of rat adrenal glomerulosa cells. Angiotensin II (Ang II) vs. Control cells was evaluated on Cell proliferation and protein synthesis. A 3-day treatment with Angiotensin II increased protein synthesis and decreased proliferation in cultured rat adrenal glomerulosa cells via p42/p44mapk and p38 MAPK pathways.
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