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April 1, 1996Hypertension

Angiotensin II Is Mitogenic for Cultured Rat Glomerular Endothelial Cells

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Population

Primary cultures of rat glomerular endothelial cells

Comparison

Angiotensin II (Ang II) vs Quiescent cells (control)

Design

Preclinical

Authors

GWGünter WolfThe Wistar InstituteFZFuad N. ZiyadehAmerican University of Beirut Medical CenterGZGunther ZahnerUniversität Hamburg

Discussion

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Implication

Should not change practice; hypothesis-generating for AT1-mediated glomerular endothelial proliferation in hypertensive renal injury.

Structured PICO

P
Population
Primary cultures of rat glomerular endothelial cells
I
Intervention
Angiotensin II (Ang II)
C
Comparator
Quiescent cells (control)
O
Outcome
Cell proliferation (measured by [3H]thymidine incorporation and direct cell counting)surrogate

Angiotensin II acts as a moderate mitogen for rat glomerular endothelial cells via AT1 receptors, suggesting a potential role in the pathophysiology of glomerulonephritis and hypertensive renal injury.

Cite This Study

Wolf et al. (1996) studied this question.

synapsesocial.com/papers/6a856475f8226fba7f1095a0https://doi.org/10.1161/01.hyp.27.4.897
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ANG II is a mitogen for a murine cell line isolated from medullary thick ascending limb of Henle's loop1995 · 37 citations
  2. 2Platelet-derived growth factor and angiotensin II stimulate the mitogen-activated protein kinase cascade in renal mesangial cells: comparison of hypertrophic and hyperplastic agonists1995 · 114 citations
  3. 3Angiotensin II induces cellular hypertrophy in cultured murine proximal tubular cells1990 · 209 citations
  4. 4Components of the angiotensin system cause release of a neutrophil chemoattractant from cultured bovine and human endothelial cells1990 · 51 citations