Why the study?
Do specific ET-1 receptor antagonists suppress proliferation and fibronectin production in cultured rat mesangial cells stimulated with Angiotensin II?
Population
Cultured rat mesangial cells stimulated with Angiotensin II
Comparison
Specific ET-1 receptor antagonists BQ123 and… vs Control/Ang-II stimulation alone
Design
Preclinical
Authors
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ET-A antagonism may modulate Ang-II-driven mesangial responses in vitro; leaves open translation to human renal disease.
Do specific ET-1 receptor antagonists suppress proliferation and fibronectin production in cultured rat mesangial cells stimulated with Angiotensin II?
ET-1 type A receptor antagonists can partly suppress Angiotensin II-induced proliferation and fibronectin production in rat mesangial cells.
Kuo et al. (2006) studied this question.
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