What does this research mean for the field?

Endothelin-1 and Angiotensin II mutually stimulate matrix protein synthesis and mesangial cell mitogenesis through ETA and AT1 receptors via interdependent mechanisms involving protein kinase C activation, TGF-beta synthesis, and the cross-release of one peptide by the other. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1996Hypertension

Effects and Interactions of Endothelin-1 and Angiotensin II on Matrix Protein Expression and Synthesis and Mesangial Cell Growth

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Population

Rat mesangial cells

Comparison

Endothelin-1 and Angiotensin II at various… vs Control conditions

Design

Preclinical

Follow-up

24 hours

Authors

DGDulcenombre Gómez‐GarréPreventive Cardiology MRMarta Ruiz‐OrtegaVascular / Pulmonary Vascular MOMónica OrtegoClinica Universidad de Navarra

Discussion

Member takes

Implication

Supports ET-1/Ang II interplay in mesangial matrix synthesis; hypothesis-generating for dual ETA/AT1 blockade in glomerulosclerosis.

Structured PICO

Population

Rat mesangial cells

Intervention

Endothelin-1 (ET-1) and Angiotensin II (Ang II) at various concentrations

Comparator

Control conditions (0.5% fetal calf serum, unrelated IgG)

Outcome

Fibronectin and type IV collagen mRNA expression, fibronectin synthesis, and mitogenesissurrogate

ET-1 and Ang II stimulate matrix protein synthesis and mesangial cell mitogenesis through ETA and AT1 receptors, suggesting a complex interplay in the pathogenesis of glomerulosclerosis.

Cite This Study

Gómez‐Garré et al. (1996) studied this question.

synapsesocial.com/papers/6a1e774e20458ccdef55e83f https://doi.org/10.1161/01.hyp.27.4.885

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Effects and Interactions of Endothelin-1 and Angiotensin II on Matrix Protein Expression and Synthesis and Mesangial Cell Growth

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects and Interactions of Endothelin-1 and Angiotensin II on Matrix Protein Expression and Synthesis and Mesangial Cell Growth

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider