June 1, 1993AJP Renal Physiology
Endothelin modulates angiotensin II-induced mitogenesis of human mesangial cells
Population
Human mesangial cells (HMC) in culture
Comparison
Angiotensin II (10 M) with or without insulin… vs Control culture conditions
Design
Preclinical
Follow-up
48 hours
Authors
Discussion
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Member takes
Implication
ET-1 mediation of ANG II mitogenesis in mesangial cells remains preclinical; leaves open targeted therapies for glomerular disease.
Structured PICO
P
Population
Human mesangial cells (HMC) in culture
I
Intervention
Angiotensin II (10(-8) M) with or without insulin, ET-1 monoclonal antibody, or ANG II-receptor antagonist DuP 753
C
Comparator
Control culture conditions
O
Outcome
Mitogenesis (measured by [3H]thymidine incorporation and cell counts) and endothelin production at 48 hourssurrogate
Angiotensin II acts as a mitogen in human mesangial cells, an effect that is partially mediated by endothelin and potentiated by insulin.
Cite This Study
Bakris et al. (1993) studied this question.