Population
Human mesangial cells (HMC) in culture
Comparison
Angiotensin II with or without losartan… vs Control cells (untreated)
Design
Preclinical
Follow-up
up to 24 hours
Authors
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AngII-AT1 signaling may drive mesangial VEGF secretion; leaves open its role in human renal disease and any therapeutic implications.
Angiotensin II stimulates the synthesis and secretion of VPF/VEGF in human mesangial cells via AT1 receptors, suggesting a mechanism for endothelial cell regulation in renal diseases.
Pupilli et al. (1999) studied this question.
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