July 1, 1994American Journal of Hypertension
ACE Inhibitor-Mediated Attenuation of Mesangial Cell Growth: A Role for Endothelin
Why the study?
Do ACE inhibitors and losartan attenuate human mesangial cell growth through a reduction in endothelin-1 generation?
Population
Human mesangial cells (HMCs) in culture (quiescent and proliferating)
Comparison
Four different ACE inhibitors, losartan, and a… vs Vehicle
Design
Preclinical
Authors
Discussion
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Implication
Losartan may suppress mesangial endothelin-1 more than ACE inhibitors in vitro; hypothesis-generating and should not change practice.
Structured PICO
Do ACE inhibitors and losartan attenuate human mesangial cell growth through a reduction in endothelin-1 generation?
P
Population
Human mesangial cells (HMCs) in culture (quiescent and proliferating)
I
Intervention
Four different ACE inhibitors, losartan, and a monoclonal antibody to endothelin-1, with or without insulin
C
Comparator
Vehicle
O
Outcome
HMC-associated mitogenesis, cell counts, and endothelin-1 productionsurrogate
ACE inhibitors and losartan inhibit human mesangial cell mitogenesis and reduce endothelin-1 production, providing evidence that Ang II production may occur in culture media when precursors and converting enzyme activity are present.
Limitations
- The kinetics of this reaction, as well as the mechanism of how insulin potentiates the antimitogenic effects of ACEIs, were not studied.
Cite This Study
Bakris et al. (1994) studied this question.