Key result
Exposure of cultured rat mesangial cells to ET-1 increased preproET-1 mRNA expression to 465% of control values (p<0.01), an effect mediated by the ETB receptor subtype.
Population
Cultured rat glomerular mesangial cells
Comparison
Incubation with endothelin-1, ETB-specific… vs Non-stimulated cells (control values)
Design
Preclinical
Authors
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No immediate clinical implications; leaves open ETB-mediated ET-1 autoregulation in human glomerular disease.
p-value: p=<0.01
In rat mesangial cells, autoinduction of ET-1 occurs through the ETB receptor subtype via increases in both preproET-1 transcription and mRNA stability.
Iwasaki et al. (1995) studied this question. Endothelin-1 (ET-1) vs. Control (non-stimulated cells) was evaluated on preproET-1 mRNA expression (p=<0.01). Exposure of cultured rat mesangial cells to ET-1 increased preproET-1 mRNA expression to 465% of control values (p<0.01), an effect mediated by the ETB receptor subtype.
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