Key result
Co-stimulation of human mesangial cells with thrombin and TNFalpha synergistically upregulated preproET-1 gene expression via p38 MAPK and PKC pathways, overcoming negative promoter modulation.
Population
Human mesangial cells
Comparison
Co-stimulation with thrombin and tumor necrosis… vs Thrombin alone or unstimulated cells
Design
Preclinical
Authors
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May inform ET-1 regulation in inflammatory renal disease; hypothesis-generating and requires in vivo confirmation before any clinical consideration.
Co-stimulation with thrombin and TNFalpha synergistically upregulates preproET-1 expression in human mesangial cells via p38 MAPK and PKC pathways, suggesting a mechanism for ET-1 production in inflammatory renal disease.
Foschi et al. (2001) studied Renal inflammation. Thrombin and TNFalpha co-stimulation vs. Thrombin alone was evaluated on preproET-1 gene expression. Co-stimulation of human mesangial cells with thrombin and TNFalpha synergistically upregulated preproET-1 gene expression via p38 MAPK and PKC pathways, overcoming negative promoter modulation.
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