Why the study?
Does thrombin induce preproET-1 gene expression and ET-1 peptide secretion in endothelial cells via specific signal transduction pathways?
Population
Macrovascular cells and microvascular cells
Comparison
Thrombin (4 U/mL) vs Untreated cells and cells treated with inactive…
Design
Preclinical
Follow-up
1 to 2 hours
Authors
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No immediate clinical implications; leaves open PTK as a target for mechanistic studies of endothelial ET-1 regulation.
Does thrombin induce preproET-1 gene expression and ET-1 peptide secretion in endothelial cells via specific signal transduction pathways?
Thrombin induces endothelin-1 gene expression and peptide synthesis in endothelial cells through a protein tyrosine kinase-dependent pathway.
Marsen et al. (1995) studied this question.
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