Key result
Thrombin stimulates the simultaneous release of endothelin-1 and big endothelin-1 from cultured porcine endothelial cells via a mechanism likely involving intracellular Ca2+ mobilization and PKC activation.
Why the study?
Does thrombin stimulate the release of endothelin-1 and big endothelin-1 in cultured porcine endothelial cells via PKC activation and Ca2+ mobilization?
Does thrombin stimulate the release of endothelin-1 and big endothelin-1 in cultured porcine endothelial cells via PKC activation and Ca2+ mobilization?
Thrombin stimulates the simultaneous release of endothelin-1 and big endothelin-1 from endothelial cells through mechanisms involving protein kinase C and calcium mobilization.
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Should not change clinical practice; leaves open translation of thrombin–endothelin mechanisms from porcine cells to human disease.
Kohno et al. (2008) studied this question. Thrombin vs. Basal release was evaluated on Release of immunoreactive endothelin-1 and big endothelin-1. Thrombin stimulates the simultaneous release of endothelin-1 and big endothelin-1 from cultured porcine endothelial cells via a mechanism likely involving intracellular Ca2+ mobilization and PKC activation.
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