Key result
Cultured bovine glomerular capillary endothelial cells express and secrete endothelin-1 in a phospholipase C-regulated manner when stimulated by agonists such as bradykinin.
Population
Cultured bovine glomerular capillary endothelial cells (GEN)
Design
Preclinical
Authors
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May implicate glomerular ET-1 pathways; leaves open relevance to human renal disease.
Glomerular capillary endothelial cells can express and secrete ET-1 in a phospholipase C-regulated manner, suggesting a potential paracrine regulation of mesangial cell tone.
Marsden et al. (1991) studied this question. Bradykinin and other calcium-mobilizing agonists was evaluated on Endothelin secretion and preproendothelin 1 mRNA expression. Cultured bovine glomerular capillary endothelial cells express and secrete endothelin-1 in a phospholipase C-regulated manner when stimulated by agonists such as bradykinin.
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