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January 1, 1993Journal of the American Society of Nephrology

Glomerular epithelial cells produce endothelin-1.

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Population

Cultured rat glomerular epithelial cells, bovine pulmonary artery endothelial cells, and rat mesangial cells

Comparison

Stimulation with transforming growth… vs Unstimulated basal culture conditions

Design

Preclinical

Follow-up

24 hours

Authors

ACAndrey V. CybulskyMcGill University Health CentreDSDuncan J. StewartHeart Failure & TransplantMCMyron I. CybulskyGeneral / Preventive / Lipids

Discussion

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Implication

Glomerular epithelial cells produce ET-1 under inflammatory stimuli; extends known sources but leaves open relevance to human glomerular disease.

Structured PICO

P
Population
Cultured rat glomerular epithelial cells, bovine pulmonary artery endothelial cells, and rat mesangial cells
I
Intervention
Stimulation with transforming growth factor-beta, complement C5b-9, thrombin, phorbol myristate acetate, or epidermal growth factor; and inhibition with 1-(5-isoquinolinyl-sulfonyl)-3-methyl-piperazine
C
Comparator
Unstimulated basal culture conditions
O
Outcome
Synthesis and release of endothelin-1 peptide and preproendothelin-1 mRNAsurrogate

Glomerular epithelial cells are capable of producing endothelin-1, which is upregulated by proinflammatory molecules and may influence glomerular hemodynamics.

Cite This Study

Cybulsky et al. (1993) studied this question.

synapsesocial.com/papers/6a894143b4e829b19bd43ca6https://doi.org/10.1681/asn.v371398
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulated expression of endothelin 1 in glomerular capillary endothelial cells1991 · 107 citations
  2. 2Angiotensin II Is Mitogenic for Cultured Rat Glomerular Endothelial Cells1996 · 81 citations
  3. 3Endothelin Receptor Subtype B Mediates Autoinduction of Endothelin-1 in Rat Mesangial Cells1995 · 86 citations
  4. 4Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways.1989 · 418 citations
  5. 5Induction of Endothelin Secretion by Angiotensin II1991 · 61 citations