Key result
Endothelin at low concentrations (0.1-10 nM) induced a 5.8-fold increase in mitogenesis in quiescent rat glomerular mesangial cells.
Why the study?
Does endothelin stimulate mitogenesis and related biochemical signals in rat mesangial cells?
Population
Quiescent rat glomerular mesangial cells in culture
Design
Preclinical
Authors
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Endothelin may promote mesangial proliferation in animal models; leaves open its role in human glomerular disease.
Does endothelin stimulate mitogenesis and related biochemical signals in rat mesangial cells?
Effect estimate: 5.8-fold increase
p-value: p=<0.01
Endothelin functions not only as a vasoconstrictor but also as a mitogen in rat mesangial cells, likely via phospholipase C activation.
Simonson et al. (1989) studied None (healthy rat mesangial cells). Endothelin vs. Vehicle/Control (0.5% FBS or 1.0% BSA) was evaluated on [3H]thymidine uptake (mitogenesis) (5.8-fold increase, p=<0.01). Endothelin at low concentrations (0.1-10 nM) induced a 5.8-fold increase in mitogenesis in quiescent rat glomerular mesangial cells.
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