Key result
Exogenous and locally synthesized angiotensin II acted as an autocrine factor to stimulate aldosterone secretion and suppress cell proliferation in cultured bovine glomerulosa cells.
Why the study?
Does exogenous and locally synthesized angiotensin II affect aldosterone secretion and cell proliferation in cultured bovine glomerulosa cells?
Population
Cultured bovine glomerulosa cells
Design
Preclinical
Follow-up
24 to 72 hours
Authors
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Leaves open human relevance in hypertension; hypothesis-generating for autocrine angiotensin II effects on aldosterone.
Does exogenous and locally synthesized angiotensin II affect aldosterone secretion and cell proliferation in cultured bovine glomerulosa cells?
Angiotensin II is locally synthesized by bovine glomerulosa cells and acts as an autocrine factor to stimulate aldosterone secretion and inhibit cell proliferation.
Horiba et al. (1990) studied Cultured bovine glomerulosa cells. Angiotensin II was evaluated on Aldosterone secretion and cell proliferation. Exogenous and locally synthesized angiotensin II acted as an autocrine factor to stimulate aldosterone secretion and suppress cell proliferation in cultured bovine glomerulosa cells.
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