November 1, 2000Hypertension
Action of Angiotensin II on DNA Synthesis by Human Saphenous Vein in Organ Culture
Why the study?
Does Angiotensin II stimulate DNA synthesis in deendothelialized human saphenous vein in organ culture?
Population
Deendothelialized human saphenous vein in organ culture
Comparison
Angiotensin II in medium containing 0.4% fetal… vs Medium containing only 0.4% fetal calf serum
Design
Preclinical
Follow-up
7 days
Authors
Discussion
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Member takes
Implication
Ang II may drive venous hyperplasia via AT1 and tyrosine kinase; leaves open in vivo relevance and therapeutic translation.
Structured PICO
Does Angiotensin II stimulate DNA synthesis in deendothelialized human saphenous vein in organ culture?
P
Population
Deendothelialized human saphenous vein in organ culture
I
Intervention
Angiotensin II (Ang II) in medium containing 0.4% fetal calf serum for 7 days
C
Comparator
Medium containing only 0.4% fetal calf serum
O
Outcome
DNA synthesissurrogate
Angiotensin II stimulates DNA synthesis in human saphenous vein organ cultures, partially via AT1 receptors and tyrosine kinase pathways.
Cite This Study
Ibrahim et al. (2000) studied this question.