Key result
Angiotensin II stimulates DNA synthesis in cultured vascular smooth muscle cells through an AT1A receptor subtype, which is antagonized by losartan at nanomolar concentrations.
Population
Cultured rat aortic vascular smooth muscle cells (VSMC)
Comparison
Angiotensin II and various angiotensin II… vs Basal conditions or Angiotensin II alone
Design
Preclinical
Authors
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Supports AT1A targeting to curb VSMC proliferation; leaves open whether losartan confers clinical vascular benefits beyond BP control.
Angiotensin II stimulates DNA synthesis in vascular smooth muscle cells primarily through the AT1A receptor subtype.
Briand et al. (1994) studied Cultured vascular smooth muscle cells. Angiotensin II and AT1 receptor antagonists vs. Basal conditions was evaluated on [3H]-thymidine incorporation (DNA synthesis). Angiotensin II stimulates DNA synthesis in cultured vascular smooth muscle cells through an AT1A receptor subtype, which is antagonized by losartan at nanomolar concentrations.
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