What is the clinical evidence from this study?

Study design: Other. Intervention: Angiotensin II (AII). Primary outcome: DNA synthesis and cellular proliferation.

September 15, 1994Biochemical JournalOpen Access

Activation of AT1 angiotensin receptors induces DNA synthesis in a rat intestinal epithelial (RIE-1) cell line

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Key result

Angiotensin II stimulated DNA synthesis and cellular proliferation in the RIE-1 rat intestinal epithelial cell line via the AT1 receptor.

Why the study?

Does angiotensin II stimulate DNA synthesis and cellular proliferation in rat intestinal epithelial cells?

Population

Rat intestinal epithelial cell-line (RIE-1)

Design

Preclinical

Authors

RSRoger SmithTwitter (United States)ACAnthony N. CorpsAddenbrooke's Hospital KHKathryn HadfieldBabraham Institute

Discussion

Member takes

Implication

AII may stimulate epithelial proliferation in vitro; leaves open AT1 role in intestinal regeneration or disease.

Structured PICO

Does angiotensin II stimulate DNA synthesis and cellular proliferation in rat intestinal epithelial cells?

Population

Rat intestinal epithelial cell-line (RIE-1)

Intervention

Angiotensin II (AII) at concentrations of 10-100 nM

Outcome

DNA synthesis and cellular proliferationsurrogate

Angiotensin II acts as a mitogen for rat intestinal epithelial cells via the AT1 receptor, activating the inositol lipid signalling pathway.

Cite This Study

Smith et al. (1994) studied this question. Angiotensin II (AII) was evaluated on DNA synthesis and cellular proliferation. Angiotensin II stimulated DNA synthesis and cellular proliferation in the RIE-1 rat intestinal epithelial cell line via the AT1 receptor.

synapsesocial.com/papers/6a6b7ec6425eb3a8efb38d65 https://doi.org/10.1042/bj3020791

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