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January 1, 1995American Journal of Hypertension

Development of structural vascular changes with subpressor angiotensin II administration in rats

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Why the study?

Does subpressor angiotensin II administration induce structural vascular changes in rats?

Population

Male Sprague-Dawley rats (350 to 400 g)

Comparison

Angiotensin II administered intraperitoneally at… vs Sham-treated rats (controls)

Design

Preclinical

Follow-up

Up to 6 weeks

Authors

GSG SIMONMinneapolis VA Medical CenterGCGabor CserepRoland Hill (United Kingdom)CLConstantinos J. LimasUniversity of Minnesota

Discussion

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Implication

Subpressor angiotensin II may promote regional vascular remodeling in rats; leaves open translation to human hypertension.

Structured PICO

Does subpressor angiotensin II administration induce structural vascular changes in rats?

P
Population
Male Sprague-Dawley rats (350 to 400 g)
I
Intervention
Angiotensin II (ANG II) administered intraperitoneally at 200 ng/kg/min for 7 to 10 days or 6 weeks, or 100 ng/kg/min for 6 weeks
C
Comparator
Sham-treated rats (controls)
O
Outcome
Wall-to-lumen ratios of mesenteric and renal arteriessurrogate

Long-term administration of initially subpressor doses of angiotensin II leads to significant regional structural vascular changes in rats.

Cite This Study

SIMON et al. (1995) studied this question.

synapsesocial.com/papers/6a855dcd90c4f21ff9d59af7https://doi.org/10.1016/0895-7061(94)00192-e
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II causes vascular hypertrophy in part by a non-pressor mechanism.1991 · 397 citations
  2. 2Angiotensin-induced hypertension in the rat. Sympathetic nerve activity and prostaglandins.1989 · 105 citations
  3. 3Chronic angiotensin II infusion decreases renal norepinephrine overflow in conscious dogs.1984 · 71 citations
  4. 4Blunted effects of endothelin upon small subcutaneous resistance arteries of mild essential hypertensive patients1992 · 108 citations
  5. 5Effects of a beta-blocker or a converting enzyme inhibitor on resistance arteries in essential hypertension.1994 · 264 citations