October 1, 1998HypertensionOpen Access

Structural Vascular Changes in Hypertension

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Population

Male Sprague-Dawley rats

Comparison

Angiotensin II subcutaneously at 50, 100, or 200… vs Sham-operated rats fed normal sodium or high…

Design

Preclinical

Follow-up

4 or 12 weeks

Authors

GSGéza SimonUniversity of Minnesota GÍGyörgy ÍllyésBon Secours Hospital Cork BCB. CsikyUniversity of Pecs

Discussion

Member takes

Implication

No immediate clinical implications; extends preclinical evidence of Ang II-salt synergy on BP and remodeling, leaving human translation open.

Structured PICO

Population

Male Sprague-Dawley rats

Intervention

Angiotensin II (Ang II) subcutaneously at 50, 100, or 200 ng/kg/min for 4 or 12 weeks on normal sodium diet (0.7% NaCl) or 50 ng/kg/min Ang II SC for 12 weeks on high sodium diet (2% NaCl)

Comparator

Sham-operated rats fed normal sodium (0.7% NaCl) or high sodium diet (2% NaCl)

Outcome

Systolic blood pressure and wall-to-lumen ratio (W/L) of mesenteric resistance arteriessurrogate

Angiotensin II induces dose- and time-dependent hypertension and structural vascular changes that are synergistically enhanced by dietary sodium supplementation, indicating a direct trophic effect of Ang II.

Cite This Study

Simon et al. (1998) studied this question.

synapsesocial.com/papers/6a83d650b5a613d8fb3e9945 https://doi.org/10.1161/01.hyp.32.4.654

Topics

Hypertension management

View Full Paper

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Bookmark

Implication

No immediate clinical implications; extends preclinical evidence of Ang II-salt synergy on BP and remodeling, leaving human translation open.

Structural Vascular Changes in Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Structural Vascular Changes in Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider